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The THY1 + FLS are located in the sublining layer and have distinct functional properties, including perivascular, pro-inflammatory and DKK3 expression, each of which is associated with different aspects of synovial pathology

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As an alternative strategy to target IGF signaling, results of phase 1 clinical trials of the dual IGF1/2-neutralizing antibodies have been reported, while no results of phase 2/3 trials in cancer therapy have been reported [156, 157]

Some peptides also interact indirectly with the microbiome by modulating local immune responses or influencing signaling pathways that affect bacterial colonization and metabolism