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When these pathways become dysregulated, they can contribute to cancer progression (Fig
490 Leptin, which is secreted by adipose tissue, regulates energy homeostasis, with increased fat reserves typically leading to increased circulating leptin levels
Yi C, Troutman S, Fera D, Stemmer-Rachamimov A, Avila JL, Christian N, et al
Another important aspect of their research is that, for this system to function, the correct activity and coordinated action of the various enzymes involved in its complete breakdown are required, highlighting the complexity of these pathways and the ability of tumour cells to adapt and activate alternative metabolic routes
Malignant transformation of GI endometriosis, though extremely rare, represents a clinically significant complication
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