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when the liver undergoes ischemiareperfusion injury due to hyperthermia, acute kidney injury often complicates the condition, and this combined injury significantly increases patient morbidity and mortality [76]

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Based on this and in other experimental evidence [Citation5,Citation83] it has been purposed that hyperuricemia could be a compensatory mechanism to mitigate oxidative damage in humans and that elevated UA levels in cardiovascular disease would reflect a beneficial response to the oxidative stress commonly associated with this condition

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