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Other Medical Conditions Consult your doctor before using vitamin B12 supplements if you have or have had kidney disease, infectious disease, liver disease, malabsorption, cancer, gout, or blood disorders such as polycythemia vera

doi: 10.1016/S0006-3223(97)00277-1

This may happen when there is a buildup of trapped bile and fat in the liver, which not only slows down metabolism but also can lead to other serious health complications