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From there, a personalized plan is built, which may include prescription medication, nutrition guidance, lifestyle adjustments, and ongoing monitoring

Week 1-2 Initial tissue healing response begins Week 2-4 Visible skin improvements may begin Week 4-8 Collagen synthesis and regeneration effects Week 8-12 Peak effects

doi: 10.1038/nrendo.2018.22 8 CuevasRamosDFleseriuM

Retatrutide lowered weight by up to an average of 28.7% (32.2 kgs) in 68 weeks the highest among all weight-loss drugs - and reduced knee osteoarthritis pain by an average of 4.5 points (75.8%) using the validated pain score tool WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index)

What matters most is that you start with accurate information, realistic expectations, and a provider you trust