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La sintesi endogena avviene a partire dal substrato TML (6-N-trimetillisina), che a sua volta deriva dalla metilazione dell'amminoacido lisina

The relatively short half-life, compared with longer-acting compounds in the broader GH-axis class, is part of why Ipamorelin produces a pulsatile, physiologically patterned GH release rather than a sustained elevation, which is one of the reasons it remains a preferred reference tool for studying pulsatile GH secretion patterns

Or they might simply operate more efficiently

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As telomeres shorten with age, cell division becomes limited, accelerating the aging process