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The manufacturer receives patent protection, typically lasting 20 years from the filing date, though effective market exclusivity is often shorter due to the time required for development and approval

But rotating injection sites and improving technique (such as injecting more slowly) can help reduce the chance of recurring hard spots

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Research published in the American College of Gastroenterology journal confirmed this connection, finding that GLP-1 receptor agonists are associated with increased risk of gastroesophageal reflux in susceptible patients