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In the exogenous pathway, the generation of ROS is driven by extracellular stimuli, including hypoxia, growth factors, inflammatory mediators, ionizing radiation, and heavy metals ( Figure 1 )

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When antibiotics, particularly Sulphur drugs, are used for extended periods, the normal synthesis of Folic acid in the gut will be reduced, and the requirement for Folic Acid are increased

Available from: Winston AW, Rinehart RS, Riley GP, Vacchiano CA, Pellegrini JE

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