New @Nature A quintuple [GLP-1 + 4 other] receptor agonist drug that exceeds effects of the dual receptor (GLP-1 and GIP, tirzepatide) in the experimental model vs diabetes and obesity (in case you thought a dual receptor was max effect, as also seen with retatrutide, a triple pic.twitter.com/bvjCbj5Y6P - Eric Topol (@EricTopol) April 29, 2026 Journal reference: Liskiewicz, D., Novikoff, A., Khalil, A
doi:10.1371/journal.pgen.1006950 Solomou A, Meur G, Bellomo E, Hodson DJ, Tomas A, Li SM, Philippe E, Herrera PL, Magnan C, Rutter GA (2015) The zinc transporter Slc30a8/ZnT8 is required in a subpopulation of pancreatic -cells for hypoglycemia-induced glucagon secretion
3) Other prescription weight-loss medicines (some injectable, many oral) There are other weight-management medications with different mechanisms (some reduce fat absorption, some act centrally on appetite)
Clinical trials across autoimmune diseases indicate a potential role for metformin as an adjunct therapy
Going below 3.0V per cell causes permanent damage and reduces future capacity