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Abstract Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that mainly damages the hands and feet, which affects 0.5% to 1.0% of the population worldwide
This abnormality has been identified in 10% of pigmented neurons in the substantia nigra and over 50% in the locus coeruleus in PD [20]
But, too much can be bad
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