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The safety profile of oral glutathione is far better supported, and it is far more practical for everyday use

Clin Invest Med 35(6):E370E377 Langston W, Circu ML, Aw TY (2008) Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose

The strongest case for early intervention exists in adults who meet all of the following: BMI of 30 or greater (or 27 or greater with cardiometabolic risk factors), fasting insulin or HOMA-IR in the insulin-resistant range, family history of type 2 diabetes, and a pattern of progressive weight gain despite lifestyle efforts