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These include compounds such as racetams and peptides with drug-like properties

For instance, semaglutide alleviates physical limitations in HFpEF patients, while tirzepatide reduces the composite endpoint of cardiovascular death or worsening HF in obese patients with HFpEF-underscoring their broad utility in cardiometabolic disease management

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Figure EV5 MC5-R activation with PG-901 reduced the number of apoptotic cells in the heart of TAC-operated mice

It is a high affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively)