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The ubiquitin-proteasome system (UPS) ensures that clock proteins are cleared at precise times within the circadian cycle, a process which is essential for resetting the molecular clock and sustaining robust circadian rhythms

Polyphosphoinositide homeostasis represents a balance between synthesis via the actions of various kinases and turnover via the actions of various phosphoinositide phosphatases

The time course of drug in the body will depend on both the volume of distribution and the clearance: Because drug elimination can be described by an exponential process, the time taken for a twofold decrease can be shown to be proportional to the natural logarithm of 2