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Description

It could increase the metabolic rate of fat beta-oxidation and accelerate fat consumption in cells (mitochondria)

coli deletion mutant was screened at least twice

By analyzing RNA sequencing data, we found the increase in ATF4-mediated transcriptional network for the upregulation of SHMT2 for dTTP in T315I-Bcr-Abl-32D cells

References: He, B., Wang, F., & Qu, L

Biochimica et Biophysica Acta (BBA) 1842:12401247 Wong HS, Dighe PA, Mezera V, Monternier PA, Brand MD (2017) Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions