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They often reflect: Metabolic adaptation (your body becoming more efficient) Inadequate protein or nutrient intake Reduced muscle mass Underlying hormone or stress imbalances This is where a more personalised, metabolic approach can help move things forward again

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Maintain 7-9 hours of quality sleep, manage stress, exercise moderately, and avoid close contact with sick individuals when possible

Conversely, non-responders exhibited lower microbial diversity and a predominance of taxa associated with metabolic impairment, most notably Prevotella copri