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The STEP clinical trial program, which evaluated higher doses of semaglutide (2.4 mg weekly) for chronic weight management, demonstrated significantly higher rates of vomiting, with approximately 20-25% of participants reporting this adverse effect during the study period

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It also showed that ACT appears to be a cost-effective treatment compared to RPT, as the ACT group incurred fewer direct costs compared to the two control arms during the 6-month study period due to lower costs for primary care visits and FM-related medications [34]

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Melatonin in Patients with Cancer Receiving Chemotherapy: A Randomized, Double-Blind, Placebo-Controlled Trial. Anticancer Research, vol