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While preclinical data is promising, its important to recognize that neither peptide is FDA-approved for human therapeutic use, and most evidence is derived from animal or laboratory studies

However, it remains as a major challenge to precisely and controllably modulate and characterize the presentation of surface ligands, which is highly relevant for large-scale manufacturing

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It induces NF-E2, Nrf-2, and NF-kB expression and decreases inflammatory markers like TNF-, IL-6, and IL-1 (242)

At the lysosomal membrane, SLC7A11 mediates proton leak, preventing hyperacidity through cystine efflux and Glu influx of lysosomes 140