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For example, a study of over 18,000 adults directly compared the weight loss effects of tirzepatide vs

If unpublished studies with null or negative findings had existed and been included, the overall effect estimate might have been attenuated

In that study, tirzepatide demonstrated an average weight loss of approximately 20% of body weight, while semaglutide came in at around 14%

Peer review Peer review information Nature Metabolism thanks Darleen Sandoval and the other, anonymous, reviewer(s) for their contribution to the peer review of this work