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Accumulation of dietary bioactives and prostate cancer (ADaPT) (2020)

Foods with ALA include red and organ meats, vegetables, and nuts and seeds

Factors affecting the degradation and drug-release mechanism of poly(lactic acid) and poly[(lactic acid)-co-(glycolic acid)]

In the Phase 3 trial SURMOUNT-1 by Jastreboff et al., 2022, the authors reported a mean weight reduction of 16.0 percent (5 mg) to roughly 22.5 percent (15 mg) versus about 3.1 percent on placebo at 72 weeks across n=2539 trial participants

Dose-Related Adverse Reactions The frequency of adverse effects (particularly elevated liver enzymes and thrombocytopenia) may be dose-related