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Six clinical studiesmostly small, randomized trialsreported 193 patients treated with topical spironolactone as 5% cream, 5% gel, 2% solution, and 1% nanogel, and 1 RCT evaluated topical flutamide gel in 27 patients

While GLP-1/GIP agonists like tirzepatide can cause a small increase in heart rate in some patients, jitteriness or tremor is not listed as a recognised adverse reaction in the official product information

Approval status (mixed): Tesamorelin (Egrifta / Egrifta SV) is FDA-approved, but only for HIV-associated lipodystrophy body-composition, muscle and anti-aging use is off-label

Medicaid expands

This is not a theoretical problem