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More recently, however, an animal study based on a tandem stenosis mouse model showed the ability of SGLT2is to stabilize atherosclerotic plaques, with increased fibrosis, augmented collagen accumulation, and significant upregulation of the expression of vasculoprotective NADPH oxidase 4 [18]

It is well tolerated by most individuals

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doi: 10.3390/antiox12010086 98 EspinoJMacedoMLozanoGOrtizRodrguezCRodrguezABet al

The PGLS gene is located on chromosome 19p13.11 and is composed of 5 exons that encode a 258 amino acid protein