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And so there's a peptide, PT141, that falls into this category of activating the melanocortican system

Effects On Blood Pressure Initiation of hydroxocobalamin infusion as part of the therapeutic interventions generally resulted in increases in blood pressure and variable changes in heart rate (often normalization)

Side effects may include injection site reactions like pain, redness, swelling, and rarely allergic reactions, dizziness, headache, nausea, diarrhoea, and skin rash

But the science is still evolving