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Behavioral testing was followed by biochemical analyses on colon, faces, serum, cerebellum, and prefrontal cortex, assessing tryptophan metabolites, serotonin (5-HT) pathway intermediates, neurotransmitters (GABA, glutamate, dopamine, acetylcholine) via UPLC, UPLC-TQD, and ELISA, alongside gut microbiota profiling through 16S r RNA sequencing

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supports glutathione-family depigmenting use but not specific to the commercial material. Reduced glutathione has mechanistic depigmenting rationale via tyrosinase inhibition, antioxidant activity, and shifting melanogenesis toward pheomelanin

[DOI] [PMC free article] [PubMed] [Google Scholar] Schilder J