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This bidirectional relationship is clinically evident in the early elevation of OS biomarkers (e.g., urinary 8-OHdG, serum F2-isoprostanes) preceding overt DM and their correlation with disease severity and complications (e.g., retinopathy, nephropathy)

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183,184 In one trial, 2,664 patients with congestive heart failure were treated with 50150 mg CoQ10 daily