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1115,1116 Oligonucleotides and small interfering RNAs (siRNAs) modulate pre-mRNA splicing or neutralize microRNAs, increasing the expression of energy-producing genes that are often downregulated in neurodegenerative conditions

The general rule of thumb is to go up slowly, and to use the lowest effective dose, thus minimizing the chance of unwanted side effects

Dopamine regulates animal aggression, while serotonin generally inhibits brain activity depending on the receptor subtype it binds to 54

Given that BSO possesses non-specific pharmacological activities, the authors concluded that this effect was independent of the inhibition of GSH biosynthesis 15

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