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Pakula R, Konikoff FM, Rubin M, Ringel Y, Peled Y, Tietz A, Gilat T

Drawing fresh doses each time The traditional approach

Decrease in Serum Bicarbonate In a trial of concomitant therapy of dapagliflozin 10 mg with exenatide extended release (on a background of metformin HCl) in adults, four patients (1.7%) on concomitant therapy had a serum bicarbonate value of less than or equal to 13 mEq/L compared to one each (0.4%) in the dapagliflozin and exenatide extended release treatment groups [see Warning and Precautions (5.2)]

This process creates a lot of dust and debris (oxidative stress)

Such supplements may also be comparatively inexpensive