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A post-mortem study showed lower levels of GSH in the prefrontal cortex of patients with MDD, bipolar disorder, and schizophrenia when compared to healthy controls (34)
Some, like Mounjaro (tirzepatide), also target a second hormone linked to appetite
While current human observational data provide reassuring safety profiles and highlight metabolic advantages, true evidence for intrinsic disease modification remains limited and heavily confounded by systemic weight loss
Bartlett JR, Smith MO
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