when does semaglutide start working GLP-1 Suppress Appetite Immediately? How Fast Does Semaglutide Work?

Semaglutide Clinical Data The STEP trial program represents the most comprehensive clinical evaluation of any GLP-1 receptor agonist for weight management: STEP 1: 14.9% mean body weight loss over 68 weeks (Wilding et al., NEJM , 2021) STEP 3: 16.0% with intensive behavioral therapy over 68 weeks STEP 5: Sustained 15.2% weight loss maintained at 104 weeks with continued treatment SELECT trial: Demonstrated 20% reduction in major adverse cardiovascular events (heart attack, stroke, cardiovascular death) in addition to weight loss, establishing cardiovascular benefit (Lincoff et al., NEJM , 2023) The SELECT trial result is particularly significant because it demonstrated that semaglutide provides cardiovascular protection independent of weight loss, a benefit that has not been established for tesofensine

GLP-1 medications also reduce blood pressure, improve lipid profiles, decrease systemic inflammation, and show renal protective effects

Now, guidelines tell us, 2-3 months, which gives GPs some leeway

& Hardingham, G

Li Y, et al