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These medications belong to a class called glucagon-like peptide-1 (GLP-1) receptor agonists , which were originally developed for type 2 diabetes management but have demonstrated significant efficacy in weight reduction

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Notably, whereas somatostatin gene knockout mice display increased glucagon and insulin release in response to nutrient stimuli compared with control mice, they show similar growth curves, islet sizes, hormone contents, resting normoglycemia and insulin sensitivity 7,11

However, TP treatment for TAO remains experimental, requiring further research to confirm its effectiveness and safety