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It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile
A deficiency in vitamin B12 during pregnancy can increase the risk of neural tube defects in the fetus, such as spina bifida
The peptides specific targeting of NNMT-expressing adipocytes allows for a localized metabolic shift without widespread systemic overstimulation, presenting a unique model for selective fat mass modulation studies
