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This is not unique to retatrutide

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doi: 10.1007/s13679-023-00534-z 61 ColbergSRSigalRJYardleyJERiddellMCDunstanDWDempseyPCet al

Dosing Window The prescribing information specifies: take oral semaglutide with no more than 4 ounces of plain water, at least 30 minutes before the first food, beverage, or other oral medication of the day [21]