Your diabetes team may consider a slower titration or temporary dose reduction if symptoms are troublesome

4.5 Serine, glycine, and threonine Serine, glycine, and threonine are closely linked to one-carbon metabolism within the metabolic network and determine the metabolic module of one-carbon metabolism-nucleotide synthesis-methyl donor generation-redox homeostasis. Unlike arginine or tryptophan, which are more oriented toward regulation through the effector molecule/receptor signaling axis, these amino acids more commonly influence inflammation-related gene expression and epigenetic states by affecting processes such as nucleotide synthesis, NADPH supply, and methyl donor generation ( Serine (Ser) can be obtained exogenously or synthesized from glycolytic intermediates through the serine synthesis pathway, in which 3-phosphoglycerate dehydrogenase (PHGDH) is the key rate-limiting step ( + accumulation and its downstream sirtuin 1 (SIRT1)/SIRT3 axis, thereby exhibiting an inhibitory effect on inflammatory output (65)

There is evidence for a deceleration of overall protein turnover with aging (3034), which suggests that the supply of cysteine and glycine could be decreased
What are safer alternatives to unregulated GLP-1 drugs
[15] [16] Regular review with your healthcare provider is essential to determine the most appropriate treatment duration for your specific circumstances, with decisions based on therapeutic response, tolerability, patient preferences, and ongoing risk-benefit assessment