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doi: 10.1006/mgme.1999.2936

Curcumin blocks IB kinase inhibitor of B kinase (IKK) activity, preventing the degradation of IB and the translocation of NF-B to the nucleus, leading to downregulation of NF-B dependent genes involved in cell growth and survival, such as cyclin D1, COX-2, and Bcl-2 family proteins (Plummer et al., 1999