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These surgeries were lengthy, required large incisions and often caused complications

Moreover, nasal sprays deliver peptides to the nasal passages in a precisely targeted manner, where they can affect either locally or systemically (e.g., in illnesses associated to the nose)

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The proportion of participants with prediabetes was 40.6% in SURMOUNT 1 34 while it was not reported in SURMOUNT 3 35 and 4 36 , enrolling patients with a mean HbA1c of 5.5%