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Birnbaum Y, Bajaj M, Qian J, Ye Y

The SURMOUNT-5 trial showed that tirzepatide produced 20.2% body weight reduction compared to 13.7% with semaglutide over 72 weeks, a significant gap that suggests tirzepatide may push past the metabolic ceiling where semaglutide stalls

T 1/2 for cagrilintide, apparent total body clearance of cagrilintide from plasma (CL/F) and apparent volume of distribution ( Vz/F ) of cagrilintide based on plasma concentration values were exploratory pharmacokinetic endpoints

Individuals with type 2 diabetes face a 1.7-fold higher risk of developing dementia 31

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