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Safety Profile Breakdown Common Side Effects : Phentermine : Dry mouth (30-40% of users) Insomnia (15-20%) Constipation (10-15%) Adderall : Appetite suppression (80-90%) Insomnia (30-40%) Anxiety (20-25%) Serious Risks : Phentermine : Pulmonary hypertension (rare) Valvular heart disease (very rare with modern formulations) Adderall : Cardiovascular events Psychiatric complications High abuse potential Cost and Accessibility Analysis Phentermine : Average monthly cost: $20-$50 (generic) Insurance coverage: Often covered for obesity treatment Prescription requirements: Schedule IV (less restrictive) Adderall : Average monthly cost: $150-$300 (generic) Insurance coverage: Rarely covered for weight loss Prescription requirements: Schedule II (strict controls) Practical Guidance for Patients Considering These Medications Who Should Consider Phentermine

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doi: 10.1016/j.peptides.2013.12.015 46 BurgmaierMLibermanAMllmannJKahlesFReithSLebherzCet al

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Mechanisms of weight regain after weight loss-the role of adipose tissue