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CR1 expression impacts the ability of erythrocytes to move immune complexes to the macrophage system for elimination (Pascual and Schifferli, 1992)
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(33176370) It may be necessary to adjust the dose of other drugs that the patient is on (e.g., phenytoin and valproate)
A systematic review of 35 prospective cohort studies assessing the association between vitamin B 12 status and cognitive deterioration in older individuals with or without dementia at baseline did not support a relationship between serum vitamin B 12 concentrations and cognitive decline, dementia, or Alzheimers disease (79)