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During menopause, declining oestrogen levels alter the body's temperature regulation, narrowing the thermoneutral zonethe temperature range within which the body maintains core temperature without triggering heat-loss mechanisms

Pradeep Kumar R, Evans DA, Dinesh Babu KV

This surge is driven by blockbuster products like Novo Nordisks Wegovy (semaglutide) and Eli Lillys Mounjaro/Zepbound (tirzepatide), whose weight-loss sales doubled or more year-over-year ( [3] ) ( [4] )

It was developed after Melanotan I (Afamelanotide)

the patient vomited a large amount of undigested food during emergence from general anesthesia