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Mechanistic sub-study embedded in an efficacy trial + Incorporate GSM/dryness endpoints (validated questionnaires, clinician assessment, pH) into semaglutide RCTs or pragmatic trials, with pre-specified subgroup analyses by menopausal status and HRT use

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Plus, doctors often recommend some of the same medications, such as selective serotonin reuptake inhibitors (SSRIs), as first-line treatments for both conditions

doi: 10.1007/s12576-016-0459-y [DOI] [PMC free article] [PubMed] [Google Scholar] 84

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