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When combined use with 5-FU, it increases the efficacy of chemotherapy in cancer, implying that microorganisms can be targeted to enhance chemotherapeutic efficacies (257)

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When Side Effects Occur What to Do GI intolerance Hold dose escalation Step back to previous dose Small frequent meals Persistent vomiting Stop drug temporarily Hydrate Check renal function Suspected pancreatitis Severe epigastric pain STOP immediately Check amylase / lipase Evaluate urgently Final Clinical Takeaways Expect meaningful weight loss in the right patient, but not every patient loses equally Avoid DPP-4 inhibitors alongside semaglutide Switching from tirzepatide to semaglutide should be cautious

Visceral fat, which accumulates around internal organs in the abdominal cavity, is particularly associated with metabolic complications including insulin resistance, dyslipidemia, and cardiovascular disease

Limitations Not for visceral fat : Only works on subcutaneous fat (3-30mm thick)