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As expected, the depletion of CSE (Extended Data Fig

This accounts for 4 weeks at each dose level: (2x4) + (4x4) + (8x4) + (12x4) = 8 + 16 + 32 + 48 = 104mg

Freckles are common in people who have a genetic predisposition to them

These mutations alter the activity of the encoded enzymes such that instead of converting isocitrate to 2-oxoglutarate (-ketoglutarate), while also generating NADPH, the mutant IDH enzymes reduce 2-oxoglutarate (-ketoglutarate) to 2-hydroxyglutarate (2-HG) while simultaneously oxidizing NADPH to NAPD +