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Gerein, V

These effects are hypothesized to stem from classical growth factor mechanisms, involving increased gene expression linked to cell growth, repair, and replacement, along with an elevation in cellular metabolism

Over time, stress, illness, and aging can disrupt this communication

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Methods: Lipodystrophic insulin resistant and glucose intolerant seipin knockout mice were treated with the GLP-1R agonist liraglutide either acutely preceding analyses of insulin and glucose tolerance or chronically prior to metabolic phenotyping and ex vivo studies