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doi: 10.1124/dmd.117.077636 148 VilahurG.BadimonJ

Proteins assessed included components of the Erk1/2 and Akt pathways, markers of oxidative stress, insulin-like growth factor-1 (IGF-1), apoptotic regulators (Bax and Bcl-2), and autophagy-associated proteins

The dose escalation chart exists for a reason

It is important to mention that, although COX-2 has traditionally been seen as an enzyme that is expressed only under pathological conditions, it has detrimental effects on the pathophysiology of diseases such as Alzheimers disease [238]

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