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The ex novo synthesis of NRF2 is triggered after exposure to low concentrations of H 2 O 2 , which precedes the translocation of NRF2 to the nucleus

We examined the combination of CoQ 10 and creatine in the 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) model of PD, the 3-nitropropionic acid (3-NP) model of HD, and in the R6/2 transgenic mouse model of HD

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For instance, Glis1-upregulated glycolysis increases lactate production and triggers histone Kla, especially H3K18la

Supernatants were collected and the protein concentrations were determined using a BCA assay kit (Pierce/Thermo Scientific, Rockford, IL) for Western blot analysis and high performance liquid chromatography (HPLC) assay