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Availability of data and materials The RNA-sequencing data has been uploaded to NCBI's Gene Expression Omnibus (GEO) and can be accessed by public ( All data generated or analyzed in this study are included in this article

Among them, the most clinically successful NRF2 activator is dimethylfumarate (DMF), authorized in Germany in 1994 for the treatment of psoriasis [281]

Formal human pharmacokinetic data on BPC-157 remain absent from published clinical literature as of 2026

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99 ADNP directly encodes a transcription factor and can bind and regulate ZFP161, which serves as a transcriptional activator of dopamine transporter (DAT