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To make matters worse, chronic diseases (e.g., type 2 diabetes and heart disease ) can deplete GSH levels, making bodily cells more prone to oxidative stress, or cell damage ( 1 , 2 , 7 )

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92,121 To date, more than 190 mutations in PKLR have been reported to be associated with pyruvate kinase deficiency (www.pklrmutationdatabase.com)

Kong L, Deng J, Zhou X, Cai B, Zhang B, Chen X, Chen Z, Wang W