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"Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial." Published in Nature Medicine, Accessed on November 13, 2023 at National Center for Biotechnology Information (NCBI)

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Gene expression for the p65 subunit of NF-B, TNF-, and COX-2 was reduced, which down-regulates the production of pro-inflammatory cytokines by GPE (86)

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Administration of MS-275, an HDAC inhibitor, also increases expression of mGlu2 receptors, supporting the role of epigenetic mechanisms in the regulation of mGlu2 receptors [30]