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Sterile Water Injection Contraindications and Warnings Never Administer Plain Water Intravenously: Do not use sterile water for direct intravenous injection without first adding an appropriate solute

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[PubMed: 4430701] 70

This is especially true if you are a vegan, are older than age 50 and of African American or Northern European descent, have an autoimmune disorder, or have had your stomach removed

Minor injection site reactions typically peak during this period as you develop technique and your body acclimates