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The docking results suggest that the positively charged guanidinium group of Arg240 interacts strongly with the carboxylate group of L -tyrosine and L -DOPA, whereas the amine group (which is predominantly positively charged at the investigated pH) of the other two substrates is electrostatically repelled (Fig

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The SURMOUNT trials showed that tirzepatide produced even greater weight reductions, in some cases exceeding 20% of baseline body weight