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A separate trial (ATTAIN-MAINTAIN) tested whether people who had already lost weight on injectable Wegovy or Mounjaro could maintain that weight loss by switching to oral orforglipron

While these synthetic GLP-1 agonists have demonstrated remarkable efficacy in clinical trials, they are associated with a range of side effects, including common gastrointestinal issues such as nausea, vomiting, diarrhea, and constipation, which are often dose-dependent (Kommu S et al., 2025

Serum CA-125 was the most common tumor marker used in assessment of follow-up after gynecological cancer treatment

The tradeoff: common side effects include nausea, vomiting, constipation, and in some cases muscle loss